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Through selection in G418, four lines were acquired that consistently expressed stabilin 2 on the cell surface (Figure 1a). We selected aged red blood cells (RBCs) as target cells, because they do not bind to phagocytes without apoptotic signals, and allow for distinction between binding and engulfment via hypotonic lysis.23 Stabilin 2 stably expressing L cells (L were shown to bind to and engulf aged RBCs (79.4 and 41.4 respectively) to a significant degree, whereas L cells transfected with the empty vector (L evidenced little binding to and absolutely no phagocytosis of aged RBCs (13.4 and 2.0 respectively) (Figures 1b and c). The interaction between RBCs and L cells was specific to aged cells, as the normal RBCs did not interact with the L cells in this assay (Figure 1c).
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Our market share for Q2 in commercial vehicles business stood at 50.3% and in passenger car business stood at 5.1 percentage. Moving over to the performance of Jaguar Land Rover, from a volume perspective the wholesale volumes compared to previous year was up 2% at 104,000 units while the retail volumes at 110,000 units were 8% higher than last year. EBITDA came in at 933 million at a margin of 19.4% reflecting the volume increase, richer product mix on the back of Range Rover Sport, Range Rover and Jaguar F TYPE, a robust market mix especially in the emerging markets and which was offset by the foreign exchange and unfavorable foreign exchange realized hedges..
