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Because loss of MUM1 function results in the absence of activated lymphoid cells and Ig secreting plasmacells,19 Tsuboi and colleagues15 reasoned that MUM1 may be developmentally regulated in lymphoid differentiation. To address this hypothesis, they have initially applied a MUM1 antiserum to reactive lymphoid tissues, showing that MUM1 expression clusters with plasma cells and, most interestingly, with a small fraction of B cells located in the light zone of the germinal center.15 As such, MUM1 expression may denote the final step of intra GC B cell differentiation, ie the stage known as centrocyte, as well as subsequent steps of B cell maturation toward plasmacells. Comparison of the topography of MUM1 and BCL 6 within the GC reveals substantial differences.
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